SEPT12 orchestrates the formation of mammalian sperm annulus by organizing SEPT12-7-6-2/-4 core complexes
نویسندگان
چکیده
منابع مشابه
SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins.
Male infertility has become a worldwide health problem, but the etiologies of most cases are still unknown. SEPT12, a GTP-binding protein, is involved in male fertility. Two SEPT12 mutations (SEPT12(T89M) and SEPT12(D197N)) have been identified in infertile men who have a defective sperm annulus with a bent tail. The function of SEPT12 in the sperm annulus is still unclear. Here, we found that ...
متن کاملSEPT 12 orchestrates the formation of mammalian sperm annulus by 1 organizing SEPT 12 - 7 - 6 - 2 / - 4 core complexes
1 Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of 6 Medicine, Taipei Medical University, Taipei 11031, Taiwan. 2 Graduate Institute of Basic 7 Medical Sciences, 3 Department of Obstetrics and Gynecology, and 4 Department of 8 Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 9 Tainan 70403, Taiwan. 5 Department of Rese...
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The septin gene belongs to a highly conserved family of polymerizing GTP-binding cytoskeletal proteins. SEPTs perform cytoskeletal remodeling, cell polarity, mitosis, and vesicle trafficking by interacting with various cytoskeletons. Our previous studies have indicated that SEPTIN12+/+/+/- chimeras with a SEPTIN12 mutant allele were infertile. Spermatozoa from the vas deferens of chimeric mice ...
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Male factor infertility accounts for approximately 50 percent of infertile couples. The male factor-related causes of intracytoplasmic sperm injection failure include the absence of sperm, immotile sperm, immature sperm, abnormally structured sperm, and sperm with nuclear damage. Our knockout and knock-in mice models demonstrated that SEPTIN12 (SEPT12) is vital for the formation of sperm morpho...
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Septins are critical for numerous cellular processes through the formation of heteromeric filaments and rings indicating the importance of structural regulators in septin assembly. Several posttranslational modifications (PTMs) mediate the dynamics of septin filaments in yeast. However, little is known about the role of PTMs in regulating mammalian septin assembly, and the in vivo significance ...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2015
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.158998